What Is Prolotherapy?

Prolotherapy is a minimally invasive, ultrasound-guided injection treatment used to help strengthen and stabilize ligaments, tendons, and joint-supporting tissues that have been strained or weakened over time. It is designed to reduce pain and improve function by supporting the body’s natural repair processes. It is most often used for chronic ligament or tendon-related pain, joint instability, or persistent discomfort following injury.
 

How It Works

Prolotherapy involves the precise injection of a higher-concentration dextrose solution (typically 12.5% to 25%) mixed with a small amount of local anesthetic. Using ultrasound guidance, the physician identifies the exact portion of ligament, tendon, or joint to directly target this injection.
 

This process stimulates local healing activity within the targeted connective tissues which may lead to reduced pain and improved stability.

Role in Comprehensive Care

Prolotherapy is typically considered when pain or looseness persists despite conservative measures such as osteopathic manipulation, physical therapy, or activity modification. It may be used as a stand-alone procedure or in combination with rehabilitation to reinforce stability as mobility and strength improve.
 

Prolotherapy is not covered by insurance.

What to Expect

The procedure is performed in the office using real-time ultrasound guidance for accuracy and safety. The skin is cleansed, and a small amount of local anesthetic is applied before the injection. Discomfort during the procedure is usually brief, and most patients find it very tolerable. Mild soreness or stiffness may occur for one to two days. Light activity can usually be resumed shortly after treatment. Results develop gradually over several weeks as the treated tissue heals, and a series of sessions is often recommended to achieve lasting benefit.

Summary

Prolotherapy uses targeted, ultrasound-guided injections of a higher-concentration dextrose solution to strengthen and stabilize ligaments, tendons, and joints. By improving structural integrity and reducing irritation, it offers a safe, conservative option for pain relief and improved function with minimal downtime. This procedure is not covered by insurance.