What Is Nerve Hydrodissection?

Nerve hydrodissection is a minimally invasive, ultrasound-guided procedure used to free a peripheral nerve from surrounding tissues that may be compressing or tethering it. Using precise ultrasound visualization, a fine needle is advanced alongside the nerve, and fluid is injected to create space around the nerve to restore normal mobility.

This technique allows the physician to directly address irritation or entrapment of nerves that can contribute to pain, tingling, or weakness in the affected region.

How It Works

Under real-time ultrasound guidance, the physician identifies the nerve and the nearby fascial or muscular layers restricting it. A small amount of sterile fluid—commonly 5% dextrose and a small amount of anesthetic—is injected to gently separate the nerve from its surrounding tissue planes.

This process:

Mechanically releases adhesions and allows the nerve to glide freely
Reduces compression on the tiny blood vessels that nourish the nerve
Improves local circulation and decreases mechanical irritation
Provides short-term numbing from the anesthetic component

In addition to helping physically free the nerve, the 5% dextrose (D5W) used in this procedure provides other benefits for nerve health. Research shows that dextrose can help calm irritated nerves and reduce abnormal pain signaling in a gentle way—without damaging the nerve—while allowing the nerve to recover and function more normally. The small amount of natural sugar in the solution also provides a mild source of energy for nearby cells, which may support local healing and tissue repair.

Together, these effects help restore motion, reduce inflammation, and promote recovery of normal nerve function.

What to Expect

The procedure is performed in the office and, including set up, usually takes less than 15-30 minutes. The skin is cleansed, and the area is numbed with a small amount of local anesthetic. The physician then uses ultrasound to guide the needle precisely next to the affected nerve before introducing the fluid.

Most patients notice a sensation of pressure or warmth as the fluid separates tissue layers. Mild soreness can occur for a day or two afterward, but recovery is typically rapid, with return to usual activity within 24–48 hours. Multiple treatments may be required in chronic or complex cases depending on the degree of nerve involvement.

Summary

Nerve hydrodissection uses targeted, ultrasound-guided fluid injection to release peripheral nerves entrapped by surrounding tissue. By restoring nerve mobility, improving circulation, and supporting nerve recovery with 5% dextrose, it offers a precise, low-risk option for symptom relief within a conservative, non-surgical treatment plan. The procedure is covered by insurance.